Norske leger i Kongo 1885-1908

1908 Scheme I + - CHOC

A synthetic strategy for the preparation of the quinone antibiotic naphthyridinomycin is outlined. An efficient synthesis of key tricyclic intermediate 6 is described. Naphthyridinomycin (I) is an architecturally interesting broad spectrum antibiotic produced by Streptomyces lusitanus. 9 1 2 The structure elucidation of 1 in I974ia,b revealed its unique hexacyclic structure which shared a quino...

Dev115253 1885..1892

Neural stem cells (NSCs) are defined by their ability to self-renew and to differentiate into mature neuronal and glial cell types. NSCs are the subject of intense investigation, owing to their crucial roles in neural development and adult brain function and because they present potential targets for gene and cell replacement therapies following injury or disease. Approaches to specifically gen...

Leon Chesley (1908-2000)

Leon Chesley studied hypertension, or high blood pressure, in pregnant women during the mid-twentieth century. Chesley studied preeclampsia and eclampsia, two hypertensive disorders found in approximately five percent of all US pregnancies. In New Jersey and New York, Chesley devoted over forty years to researching preeclampsia and eclampsia, and conducted several long-term studies using the sa...

Practical Medicine, Series 1908

Dev117903 1893..1908

Malformation of the urogenital tract represents a considerable paediatric burden, with many defects affecting the lower urinary tract (LUT), genital tubercle and associated structures. Understanding the molecular basis of such defects frequently draws on murine models. However, human anatomical terms do not always superimpose on the mouse, and the lack of accurate and standardised nomenclature ...